Lubiprostone: a novel treatment for chronic constipation
نویسندگان
چکیده
منابع مشابه
Lubiprostone: a novel treatment for chronic constipation
Chronic constipation is highly prevalent, reduces patients' quality of life, and imposes a significant health care burden on society. Lifestyle modifications and over-the-counter agents improve symptoms of constipation in some patients, however many patients have persistent symptoms and require the use of prescription medications. Three prescription medications are currently Food and Drug Admin...
متن کاملLubiprostone for the treatment of functional constipation in children.
OBJECTIVES Pediatric functional constipation is common; effective, easily administered treatment options are limited. Lubiprostone is an oral chloride channel protein-2 activator that stimulates gastrointestinal fluid secretion, softens stools, and facilitates bowel movements (BMs). We evaluated the safety and effectiveness of lubiprostone in children and adolescents with functional constipatio...
متن کاملA critical appraisal of lubiprostone in the treatment of chronic constipation in the elderly
Chronic constipation is a common disorder in the general population, with higher prevalence in the elderly, and is associated with worse quality of life and with greater health care utilization. Lubiprostone is an intestinal type-2 chloride channel activator that increases intestinal fluid secretion, small intestinal transit, and stool passage. Lubiprostone is currently approved by the US Food ...
متن کاملA Randomized Study of Lubiprostone for Opioid-Induced Constipation in Patients with Chronic Noncancer Pain
OBJECTIVE To evaluate the efficacy and safety of oral lubiprostone for relieving symptoms of opioid-induced constipation (OIC) in patients with chronic noncancer pain. DESIGN Prospective, randomized, double-blind, placebo-controlled trial. SETTING Seventy-nine US and Canadian centers. SUBJECTS Patients aged ≥ 18 years with OIC, defined as <3 spontaneous bowel movements (SBMs) per week. ...
متن کاملLubiprostone for the Treatment of Adult Women with Irritable Bowel Syndrome with Constipation
Irritable bowel syndrome with constipation (IBS-C) affects approximately 5% of the population in western countries. The majority of those afflicted are women. Symptoms are often detrimental to the individual's quality of life and incur high healthcare costs to society. There is no evidence to support changes in lifestyle, laxatives or over the counter supplements. Tegaserod appeared to have pro...
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ژورنال
عنوان ژورنال: Clinical Interventions in Aging
سال: 2008
ISSN: 1178-1998
DOI: 10.2147/cia.s2938